Low cholesterol targets cut cardiovascular events by 33%

brandonb 14 points 7 comments October 28, 2026
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Discussion Highlights (4 comments)

brandonb

The 55 mg/dL target in this study is somewhere between the 1st and 5th percentile. 70 mg/dL (the control) is around the 10th percentile. IMO, surprising that reductions at the low end still seem to yield such large benefits. I'd expect it to saturate much earlier.

westurner

ScholarlyArticle: "Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease" (2026) https://www.nejm.org/doi/full/10.1056/NEJMoa2600283

westurner

Do steak and pork from Cheesecake Factory have cholesterol?

jvanderbot

Outlive is an excellent book, and one of the excellent discussions in that book is that there is no safe level of certain kinds of cholesterol. The details are fun do read up on. It's somewhat bombastic, but a really excellent book for overall "next generation" health.

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