Fecal transplants for autism deliver success in clinical trials (2019)

davisr

So all I gotta do is eat some poop and it will save me from becoming a handsome, funny, unique genius?

jdw64

Personally, anyone looking to get a fecal transplant from Sir Demis Hassabis will have to line up behind me. I want to be first in line.

Arodex

>Editor's note: Readers often ask us for follow-ups on memorable stories. What has happened to this story over the years? This article was originally published in 2019 but it has been re-edited and updated with new information current as of April 7, 2025. Enjoy! Now that is something that should be done more often - especially in science journalism, but not only. We cruelly lack long-term vision - not only forward but backwards too.

geremiiah

What's more plausible? Did they cure low functioning autism in two years? Or did they simpily miscategorize the kids and the kids grew out of their diagnosis as they matured?

delichon

I got bad chronic constipation after four years as a strict carnivore. I didn't get relief just by adding back fiber, but I did by adding fermented foods like kimchi. I wonder if ferments are a more natural way than fecal transplants to repair the gut microbiome, possibly treating autism. Studies have been non conclusive, but this story makes me think it's worth pursuing.

ZoomZoomZoom

Absolutely outrageous/hilarious clickbait title. It's not for autism but totally opposite.

manoDev

I wonder if there’s any study linking C-section birth, autism and microbiota? Or newborns that have to stay in incubators? I understand a newborn gets its microbiota naturally by contact with the mom in the first days, maybe all the sterile environment involved in surgery changes that.

_puk

>> In early 2022 Krajmalnik-Brown and colleagues patented a specific bacterial formulation and spun-off a commercial company called Gut-Brain Axis Therapeutics. I was a little surprised to see this. So the university researchers use time and money from the university to make a discovery, extending on previous published research, and then patent it and start their own for-profit? Excuse my ignorance, but is that how it's done generally? Where's the upside for all those who are potentially affected? It kinda makes sense - Presumably the university is involved somewhere still, and it needs to be commercialised somehow, but..

directevolve

Many autistic children have extremely limited diets. For example, a geneticist friend of mine saw a case where an autistic child had been referred for genetic testing because of horrific, chronic, spontaneous wounds on gums and skin. Turned out to be scurvy, because he had exclusively eaten Wheat Thins for the last 3-4 years, which aren’t fortified with vitamin C. I would fully expect that a monotonous diet leads to a heavy skew in the gut microbiome as specific bacterial species that thrive on that diet are selected for, others against. It makes some sense that a fecal transplant could repair the damage. If the diet has shifted or expanded, the transplant could lead to long term benefits by restoring newly-viable bacterial species, perhaps by facilitating digestion of the new types of food. I’d be curious to see a factoring out of the diet composition, gut microbiome, genetics, and severity of autism symptoms.

ck2

original news source: https://news.asu.edu/20190409-discoveries-autism-symptoms-re... actual paper: https://www.nature.com/articles/s41598-019-42183-0

hank2000

The number of stories I’ve read in the last 15 years that amount to: “desperate after years of trying everything, we bought a blender and ground up my wife’s shit and put it up my butt, and within a 24 hours I was totally fine” Is kind of impressive.

senfiaj

I would still be cautious with such findings. Many autistic people are picky eaters, also some of them have issues with peristalsis. This might affect the microbiome as well. While it's plausible that it might help a subset of people, we should not overgeneralize since autism is a very heterogeneous condition, usually with pronounced genetic predisposition. Overall, it doesn't seem to be a cure.

a-dub

no placebo arm. result could be due to unisolated factors present in clinical trial fixturing.

tt_dev

Title is a bit misleading. It’s not a fecal transplant. It’s tablets and powder (for the pitt-hopkins cases) of microbes from fecal donors. Consumes orally. More like fecal food?

Aurornis

I think this is the clinical trial registration: https://clinicaltrials.gov/study/NCT03408886?tab=results It is marked as having results submitted but quality review has not been completed. N=60 and a placebo group, which is better than the N=18 and no placebo group of the first study. There have been so many small scale trials showing amazing autism improvements that failed to replicate in larger, better controlled trials. I wouldn’t get excited yet. The typical pattern is to show unbelievably good results in the first open-label trial with a small number of patients (their n=18 trial that claims to have cured severe autism in many children), squeak by with some marginal improvement in the next trial over placebo, then the third trial becomes a game of trying to keep the study small enough that they can hope to p-hack a result that the FDA might accept.

mgaunard

So if I eat somebody else's poo I'll become more social? An unexpected result for sure.

andy_ppp

AFAIK fecal transplants do not work well long term, has there been any research in making them more sticky? Lots of things you could trial but I have a feeling it’s the immune system responding to the right bacteria incorrectly…

wartywhoa23

So there is finally a huge job market to for all those affected by AI-driven workforce purges: that of fecal donorship! All applicants will be fed recycled byproducts for free.

thisisidiotic

Yeah i'm not doing that. I'll just stay this way.

Der_Einzige

First they gave them the name "assburgers" (aspergers) and now this is the solution medicine is proposing? It's like the medical community wants all high functioning autistics to get bullied like hell in their formative years. Similar irony to "lisp" being unpronounceable by the very people who have a lisp.