Scientists say they've reversed brain aging in mice with a nasal spray

bookmtn 58 points 27 comments May 27, 2026
www.sciencedaily.com · View on Hacker News

Discussion Highlights (11 comments)

wizardforhire

Was looking for the “in mice” in this article and found none… anybody got a link to the paper please

kurthr

The source paper: https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev...

trodney

Excellent news if you're a mouse.

instagib

“While additional research is still needed before the treatment could be tested in humans, the study offers a striking possibility.” (In mice)

CoastalCoder

Algernon for Flowers.

delichon

I'm afraid of the result if we take someone wrapped in a comforting haze of dementia (I'm getting there) and force them into cold harsh reality. It may be as welcome a sobriety to an alcoholic. If the insurance stops paying does it become Flowers for Algernon? We have several drugs that emulate dementia in various ways and call them recreational.

qnleigh

> Behavioral testing showed that treated models performed significantly better on memory and recognition tasks. "Treated models" - it sounds like they're trying really hard to hide the fact that this was all in mice. From the paper: > Therefore, using a mouse model, this study investigated whether IN administration of hiPSC-NSC-EVs in late middle age can significantly reduce oxidative stress and curb microglia-mediated neuroinflammaging in the hippocampus. Cool! But please be honest in your press releases.

Morromist

Imagine the political implications of this if it actually worked.

dolphinscorpion

These billionaire mice are funding this research; humans should do the same

molticrystal

edit: admin dang has fixed the title I always interpret the rule [0] "Otherwise please use the original title, unless it is misleading or linkbait; don't editorialize." as applying to stories like this one. Adding the words [in mice] would not only be the acceptable exception the rule is referring to, but probably necessary. This would align the title properly with the article contents and avoid giving people false expectations about human results. [0] https://news.ycombinator.com/newsguidelines.html

Zealotux

This headline is keeping me young because I keep reading it every five years or so.

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