Flatworms, Ion Channels, and Burning Mouths

yuye

Always love reading Derek Lowe's writings. One thing confused me, though: >These authors find that it has potent activity against the ion channel TRPM8, and that goes for other 7-nitro compounds in this series as well. But later states >For one thing, the other benzodiazepines aren’t much use; clonazepam really stands out on its own. Wouldn't another 7-nitro compound also work? Flunitrazepam/Rohypnol, for example? A little bit of research shows it actually might[1]. [1] https://pmc.ncbi.nlm.nih.gov/articles/PMC13426060/