Alzheimer's trial to test drug on people without symptoms to test prevention

orangecat

Good. If https://www.astralcodexten.com/p/in-defense-of-the-amyloid-h... is correct, the reason existing anti-amyloid drugs don't work well is amyloid leads to tau which leads to neurodegeneration, so by the time somebody is impaired by Alzheimer's they already have too much tau and reducing amyloid won't help much.

caycep

My irritation is that it's not till 7th paragraph until they tell us what the drug is. It's almost like that's not the important thing. Kinda like how political hit jobs just mentions "emails were hacked"; whether the emails had nuclear codes or the target's dry cleaning receipts is not important...